Haplogroup frequencies and Pearson's chi-square test in 843 patients with suspected LHON and 1,689 Han Chinese from the general populations.

aPooled Han Chinese were from reported populations (see Table S1 for more information).bTwo tailed Fisher exact test was applied instead of a Pearson chi-square test in cases containing cell counts below five.cAdjusted P-value: adjustment of P-values was carried out with a permutation-based approach; number of permutations = 100,000; OR (95% CI): Odds Ratio (95% Confidence Interval).dNote that haplogroup F is a sub-haplogroup of haplogroup R9 and therefore the number of F mtDNAs are also included here.

a. 本研究采用的合并汉族人群数据来自已发表的研究队列，详细信息参见附表S1。b. 当列联表单元格计数小于5时，采用双侧费希尔精确检验（Fisher exact test）替代皮尔逊卡方检验（Pearson chi-square test）。c. 校正P值：采用基于置换的方法对P值进行校正，置换次数为100000次；OR（95% CI）：优势比（Odds Ratio）的95%置信区间（95% Confidence Interval）。d. 请注意：单倍群F（haplogroup F）是单倍群R9（haplogroup R9）的亚单倍群，因此本次统计的样本量已包含F型线粒体DNA（mtDNA）的数量。