Genomics study of Klebsiella pneumoniae isolates from South and Southeast Asia

Klebsiella pneumoniae has long posed a significant challenge in clinical settings worldwide, particularly due to its carbapenemase production and multidrug-resistant (MDR) characteristics. This study aims to address the genomic characteristics of K. pneumoniae isolates from South Asia and compare them with isolates from Southeast Asia. The goal is to elucidate profiles of virulence, antimicrobial resistance (AMR), plasmids, and mobile genetic elements, as well as potential transmission dynamics, through whole-genome sequence analysis.

长期以来，肺炎克雷伯菌（Klebsiella pneumoniae）一直是全球临床环境中的重大挑战，尤其是因其产碳青霉烯酶且具备多重耐药（MDR）特性。本研究旨在解析南亚分离株的肺炎克雷伯菌基因组特征，并与东南亚分离的菌株开展对比分析。本研究拟通过全基因组测序分析，阐明其毒力、抗菌药物耐药（AMR）、质粒及移动遗传元件的特征，同时揭示潜在的传播动态。