Mapping alterations spatially and temporally during early stages of breast tumourigenesis [expression]

Identifying genomic alterations that precede tumourigenesis of breast tumours will allow us to better understand tumour development and heterogeneity. In particular, by obtaining and profiling normal-epithelium samples at various distances from the tumour, we can draft both a spatial and temporal map of the genomic events and transcriptomic alterations that occur along the mammary duct (leading up to and including the tumour). Dataset consisting of 9 patients with breast cancer, from which multiple normal epithelium samples were obtained from along the duct leading to the tumour, one sample from the contralateral duct, and a sample from the tumor itself

识别乳腺肿瘤发生（Tumourigenesis）前的基因组变异（Genomic Alterations），可助力我们更深入地理解肿瘤的发生发展与异质性（Heterogeneity）。具体而言，通过获取并分析距离肿瘤不同位置的正常上皮样本，我们能够绘制出沿乳腺导管（从肿瘤发生前直至肿瘤本身）出现的基因组事件与转录组变异（Transcriptomic Alterations）的时空图谱。本数据集共纳入9名乳腺癌患者，从中获取了沿肿瘤所在导管分布的多份正常上皮样本、1份对侧导管样本以及1份肿瘤自身样本。