Cost-free lifespan extension via optimisation of gene expression in adulthood aligns with the developmental theory of ageing

Data for the following manuscript: https://www.biorxiv.org/content/10.1101/739490v1
Please see manuscript for methods and analyses.

Provided are files for Lifespan, Reproduction and Egg size for C. elegans worms subjected to Control (empty vector) or RNAi against one of five five different genes: age-1, ife-2, ifg-1, nuo-6 or raga-1. RNAi have either been lifelong (L), during adulthood (D1=from day1 of adulthood) or post-reproductive (D6=from day 6 of adulthood).
In addition, we also provide QPCR data on gene expression downregulation of the five genes when using RNAi, see methods for details.

Some data provided may not be included in the analysis, please see
supplementary methods for details.
For the lifespan files, Event is coded as follows:Event: 1=Dead (natural death or matricide), 0=Censored
Matricide: 1=Matricide
EventWOM: 1=Dead (natural death), 0=Censored (including matricide as censored)
EventWOM is the one used in analyses.

本数据集关联以下手稿：https://www.biorxiv.org/content/10.1101/739490v1，实验方法与分析细节请参阅该文稿。
本次提供的文件涵盖秀丽隐杆线虫（C. elegans）的寿命、繁殖力与卵大小数据，受试对象分为两组：空载载体对照组，以及针对以下5个基因的RNA干扰（RNAi）处理组：age-1、ife-2、ifg-1、nuo-6及raga-1。RNA干扰处理设置了三种时长：终生处理（L）、成年期处理（D1=自成虫第1天启动）以及生殖后处理（D6=自成虫第6天启动）。
此外，本数据集还提供了使用RNA干扰（RNAi）处理后上述5个基因表达下调的定量PCR（QPCR）数据，详细信息请见实验方法章节。
部分提供的数据可能未纳入最终分析，相关细节请参阅补充实验方法章节。
针对寿命数据文件，事件编码规则如下：Event：1=死亡（自然死亡或产后致死（matricide）），0=截尾；Matricide：1=产后致死；EventWOM：1=自然死亡，0=截尾（将产后致死视为截尾数据）；分析中采用的事件编码为EventWOM。