Serum chemistry results and comparisons for wild type and HYP mice infused with vehicle or SPR4-peptide.

Mice were sacrificed on day 28 and sera prepared from 16 hour fasted mice housed in metabolic cages. Column headings represent; WT  =  wild type mice, HYP  =  X-linked hypophosphatemic rickets mice, SPR4  =  infused SPR4-peptide and Vehicle  =  Saline infused. Values are means with ± SEM (N = 6). Unpaired t tests with confidence intervals of 95% were used for statistical analysis (see also Figure 1). Superscript letters (a, b or c) added to the calculated serum values indicate; a =  significantly different to WT vehicle (WT-VE) infused mice p<0.008, b =  significantly different to HYP vehicle (HYP-VE) infused mice p<0.002 and c =  significantly different to HYP SPR4-peptide (HYP-SPR4) infused mice p<0.02. ND =  Not done. The percentage changes between WT-VE versus WT-SPR4, HYP-VE versus HYP-SPR4 and WT-VE versus HYP-VE are shown in columns 3, 6 and 7 as indicated in the headings. In these columns (3, 6 and 7), the numbers that are significantly different (p<0.01) are denoted by a superscript asterisk (*).

实验小鼠于第28天实施安乐死，采集饲养于代谢笼中且禁食16小时的小鼠血清样本。列标题定义如下：野生型小鼠（Wild Type, WT）、X连锁低磷血症性佝偻病小鼠（X-linked hypophosphatemic rickets mice, HYP）、SPR4肽输注组（SPR4）以及生理盐水输注溶剂对照组（Vehicle）。数据以平均值±标准误（Standard Error of the Mean, SEM）表示，每组样本量N=6。统计分析采用置信区间为95%的非配对t检验，相关结果参见图1。计算得到的血清数值右上角标注的上标字母（a、b或c）含义如下：a代表与生理盐水输注野生型小鼠（WT-VE）存在显著差异（p<0.008）；b代表与生理盐水输注X连锁低磷血症性佝偻病小鼠（HYP-VE）存在显著差异（p<0.002）；c代表与SPR4肽输注X连锁低磷血症性佝偻病小鼠（HYP-SPR4）存在显著差异（p<0.02）。ND表示未检测（Not Done, ND）。WT-VE与WT-SPR4组、HYP-VE与HYP-SPR4组以及WT-VE与HYP-VE组之间的百分比变化分别列于第3、6、7列，列标题已明确标注。在第3、6、7列中，数值存在显著差异（p<0.01）的结果将以上标星号（*）标注。