Circulating microRNAs as potential biomarkers in tr breast cancer translational research study of the NACATRINE trial - supplementary material

Table S1. ct-miRNA differentially expressed between pCR and RD in the carboplatin arm.Table S2. ct-miRNA differentially expressed between pCR and RD in the non-carboplatin arm.Table S3. Enrichment analysis of pathways with their respective genes involved - carboplatin arm.Table S4. Enrichment analysis of pathways with their respective genes involved – non-carboplatin arm.Figure S1: Heatmap of ct-miRNA expression data using hierarchical clustering to show the difference in expression between pCR and RD.Figure S2. Overall survival analysis by miRNA expression using Kaplan-Meier Plotter.Figure S3. Identification of differentially expressed ct-miRNAs at baseline associated with relapse: volcano plot and boxplot analysis.Figure S4. Top 10 categories of enriched genetic ontology (GO) revealed by target genes.

补充表S1：卡铂组中病理完全缓解（pathological complete response, pCR）与残留疾病（residual disease, RD）之间差异表达的循环微小RNA（circulating microRNA, ct-miRNA）。
补充表S2：非卡铂组中病理完全缓解（pCR）与残留疾病（RD）之间差异表达的循环微小RNA（ct-miRNA）。
补充表S3：卡铂组中涉及相关基因的通路富集分析。
补充表S4：非卡铂组中涉及相关基因的通路富集分析。
补充图S1：采用层次聚类分析的循环微小RNA表达热图，用于展示pCR与RD之间的表达差异。
补充图S2：基于miRNA表达的总生存分析（采用Kaplan-Meier绘图仪）。
补充图S3：基线时与复发相关的差异表达ct-miRNA的鉴定：火山图与箱线图分析。
补充图S4：靶基因富集得到的前10个基因本体（Gene Ontology, GO）条目。