Metabolic syndrome in bipolar disorder: prevalence, demographics and clinical correlates in individuals with bipolar I, bipolar II, and healthy controls

Abstract Background: The metabolic syndrome is a growing global public health problem and highly prevalent in patiens with bipolar disorder. There are a few studies about relationship between metabolic syndrome and bipolar disorder subtypes. Objective: The aim of this study was to investigate the prevalence of metabolic syndrome (MS) and its individual components in subjects with bipolar I (BD I) and bipolar II (BD II) disorder compared with non-psychiatric controls, and to determine the variables affecting MS. Methods: A total of 210 individuals (mean age 42.5 ± 11.87, 58.1% female) of whom 70 had BD I, 70 BD II, and 70 controls, were included in this study. MS was diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), the adapted ATP III (ATP III-A) and the International Diabetes Federation (IDF) criteria. Results: Participants with BD I had a significantly higher prevalence of MS when compared to individuals BD II and non-psychiatric controls according to the NCEP-ATP III, ATP III-A, and IDF criteria (ps

摘要 背景：代谢综合征（metabolic syndrome）已成为日益严峻的全球性公共卫生问题，且在双相障碍患者中患病率极高。目前针对代谢综合征与双相障碍亚型之间关联的研究较为匮乏。
目的：本研究旨在对比双相I型障碍（BD I）、双相II型障碍（BD II）患者与非精神疾病对照人群的代谢综合征（MS）及其各组分的患病率，并明确影响代谢综合征发生的相关变量。
方法：本研究共纳入210名受试者（平均年龄42.5±11.87岁，女性占比58.1%），其中双相I型障碍患者70名、双相II型障碍患者70名，非精神疾病对照70名。代谢综合征的诊断分别采用美国国家胆固醇教育计划成人治疗组第三次指南（NCEP ATP III）、修正版成人治疗组第三次指南（ATP III-A）以及国际糖尿病联盟（IDF）制定的诊断标准。
结果：依据NCEP-ATP III、ATP III-A及IDF诊断标准，双相I型障碍患者的代谢综合征患病率显著高于双相II型障碍患者及非精神疾病对照人群（ps