Additional file 2 of Genomic and immune profiling of breast cancer brain metastases

Supplementary Material 2. Pathways of interest tested. 79 pathways of interest from Hallmark pathways, KEGG, Gene Ontology (GO), and literature were selected a priori and included pathways relevant to oxidative phosphorylation, MAPK interacting serine/threonine Kinase (MNK), cyclin dependent kinase (CDK), DNA damage repair, and immune signaling. Column names include: Pathway type, biologically-relevant pathway group name; Pathway name, unique pathway identifier; Number of genes, number of genes in pathway; Source, source of pathway.

补充材料2. 经测试的目标通路
本研究预先从Hallmark特征通路集、京都基因与基因组百科全书（Kyoto Encyclopedia of Genes and Genomes，KEGG）、基因本体（Gene Ontology，GO）以及已发表文献中筛选得到79条目标通路，这些通路均与氧化磷酸化、MAPK相互作用丝氨酸/苏氨酸激酶（MAPK interacting serine/threonine Kinase，MNK）、细胞周期蛋白依赖性激酶（cyclin dependent kinase，CDK）、DNA损伤修复以及免疫信号通路相关。
列名定义如下：
通路类型（Pathway type）：生物学相关的通路组别名称；
通路名称（Pathway name）：唯一通路标识符；
基因数量（Number of genes）：单条通路包含的基因数目；
来源（Source）：通路的来源渠道。