The comparison of Macaca fascicularis gut microbiota to other mammalians and its changes under type 2 diabetes condition

The Macaca fascicularis model is widely used in scientific research and drug development as its genetics is very closed to human being. Comparing its similar feeding habits with human, the characteristics of Macaca fascicularis gut microbiota and its similarities to human and other mammalians remains unknown and knowledge of the functional interplay between the gut microbiota and host physiology in Macaca fascicularis is also limited. In our study, faecal samples from 20 Macaca fascicularis individuals were applied to metagenomic sequencing to construct the first gene catalogue of Macaca fascicularis gut bacteria. Totally 1.9 million non-redundant bacterial genes were identified.

食蟹猴（Macaca fascicularis）模型因遗传特性与人类高度相近，被广泛应用于科学研究和药物研发领域。尽管其饮食习惯与人类相似，但食蟹猴肠道微生物群（gut microbiota）的特征及其与人类和其他哺乳动物的相似性仍不明确，且关于食蟹猴肠道微生物群与宿主生理功能间相互作用的认知也十分有限。本研究中，我们对20只食蟹猴个体的粪便样本进行宏基因组测序（metagenomic sequencing），构建了首个食蟹猴肠道细菌基因目录，共鉴定出190万个非冗余细菌基因。