Supplementary materials: Antibacterial data synthesis challenges: a systematic review of treatments for complicated Gram-negative urinary tract infections

This is a peer-reviewed supplementary table for the article 'Antibacterial data synthesis challenges: a systematic review of treatments for complicated Gram-negative urinary tract infections' published in the Journal of Comparative Effectiveness Research.
Table S1. MEDLINE and EMBASE search strings.Table S2. COCHRANE LIBRARY (CENTRAL and CDSR) search strings.Table S3. PICOTS eligibility criteria for the systematic literature review.Table S4. Risk of bias assessment using the Cochrane Collaboration Tool.Table S5. Patient baseline characteristics.Figure S1. PRISMA flow diagram.Summary: Aim: To determine the suitability of network meta-analysis (NMA) using antibacterial treatment evidence in complicated urinary tract infection. Materials & methods: We conducted a systematic literature review to identify published clinical trial data for complicated urinary tract infection treatments. We performed a feasibility assessment to determine whether the available evidence would support the creation of a robust NMA, considering key assumptions of homogeneity, similarity and consistency. Results: Twenty-five trials met eligibility criteria. Risk of bias was low, and individual studies met their primary end point(s). Assumptions central to the conduct of a robust NMA were not met. Heterogeneity was ubiquitous, including baseline pathogen, treatment and patient characteristics. Conclusion: Limited and heterogeneous data identified make the use of NMA to compare novel antibacterial agents impractical and likely unreliable.

本内容为发表于《比较效果研究期刊》（Journal of Comparative Effectiveness Research）的论文《抗菌数据合成挑战：复杂性革兰阴性尿路感染治疗的系统综述》的经同行评议的补充图表集。
表S1：MEDLINE与EMBASE数据库检索策略
表S2：考克兰图书馆（Cochrane Library，含CENTRAL与CDSR）数据库检索策略
表S3：PICOTS（Population, Intervention, Comparator, Outcome, Timing, Study Design）纳入排除标准
表S4：基于考克兰协作组偏倚风险评估工具的偏倚风险评价结果
表S5：患者基线特征
图S1：PRISMA（Preferred Reporting Items for Systematic Reviews and Meta-Analyses）流程图
概述：
研究目的：明确基于抗菌治疗证据开展复杂性尿路感染网络Meta分析（network meta-analysis, NMA）的适用性。
材料与方法：本研究开展系统文献综述，检索已发表的复杂性尿路感染治疗相关临床试验数据；结合同质性、相似性与一致性三大核心假设，对现有证据能否支撑构建严谨可靠的NMA进行可行性评估。
结果：共有25项试验符合纳入标准；偏倚风险整体较低，且各项研究均达成了预设的主要结局指标。但开展严谨NMA所需的核心假设均未满足，研究间异质性普遍存在，涉及基线病原体种类、治疗方案及患者特征等多个维度。
结论：本研究检索得到的数据存在样本量有限且异质性强的问题，使得采用NMA对比新型抗菌药物的方案既不切实际，且结果大概率缺乏可靠性。