TNF-signaling modulates neutrophil-mediated immunity at the feto-maternal interface during LPS-induced intrauterine inflammation

We demonstrate that anti-TNF antibody (Adalimumab) inhibited ~80% of highly LPS-induced genes that sub-serve inflammatory signaling and innate immunity in chorio-decidua neutrophils. RNAseq of purified blood maternal neutrophils vs. FACS-sorted chorio-decidua neutrophils in a Rhesus model of intrauterine infection/inflammation

本研究证实，抗TNF抗体（Adalimumab，阿达木单抗）可抑制绒毛膜蜕膜中性粒细胞中约80%由脂多糖（Lipopolysaccharide，LPS）高度诱导的、参与炎症信号转导与固有免疫的基因。本研究在宫内感染/炎症的恒河猴模型中，对纯化的母体外周血液中性粒细胞与经荧光激活细胞分选（Fluorescence-activated cell sorting，FACS）获取的绒毛膜蜕膜中性粒细胞进行了RNA测序（RNAseq）分析。