Data from: Genomic analysis suggests KITLG is responsible for a roan pattern in two Pakistani goat breeds

The roan coat color pattern is described as the presence of white hairs
intermixed with pigmented hairs. This kind of pigmentation pattern has
been observed in many domestic species, including the goat. The molecular
mechanisms and inheritance that underlie this pattern are known for some
species and the KITLG gene has been shown associated with this phenotype.
To date, no research effort has been done to find the gene(s) that
controls roan coat color pattern in goats. In the present study, after
genotyping with the GoatSNP50 BeadChip, 35 goats that showed a roan
pattern and that belonged to two Pakistan breeds (Group A) were analyzed
and then compared to 740 goats of 39 Italian and Pakistan goats breeds
that did not have the same coat color pattern (Group B). Run of
homozygosity-based and XP-EHH analyses were used to identify unique
genomic regions potentially associated with the roan pattern. A total of 3
regions on chromosomes 5, 6 and 12 were considered unique among the group
A versus B group comparisons. The A region > 1.7 Mb on chromosome 5
was the most divergent between the two groups. This region contains six
genes, including the KITLG gene. Our findings support the hypothesis that
the KITLG gene may be associated with the roan phenotype in goats.

杂斑毛色模式（roan coat color pattern）指白色毛发与色素沉着毛发相互混合的表型。这种色素沉着模式在多种家养动物中均有观察到，包括山羊。部分物种中，该模式的分子机制与遗传规律已被阐明，且KITLG基因已被证实与该表型相关。迄今为止，尚未有研究致力于寻找调控山羊杂斑毛色模式的基因。

本研究中，使用GoatSNP50 BeadChip进行基因分型后，对35只表现出杂斑模式且属于两个巴基斯坦品种的山羊（A组）进行分析，并与39个意大利及巴基斯坦品种中未表现该毛色模式的740只山羊（B组）进行比较。基于纯合子片段（run of homozygosity）的分析及XP-EHH分析被用于识别可能与杂斑模式相关的独特基因组区域。在A组与B组的比较中，共发现5号、6号及12号染色体上的3个区域具有独特性。5号染色体上长度超过1.7 Mb的区域是两组间差异最显著的区域，该区域包含6个基因，其中包括KITLG基因。我们的研究结果支持KITLG基因可能与山羊杂斑表型相关的假设。