mRNA and DNAm references for lung

The data contains a 1788-marker expression reference and a 261-marker DNAm reference for Lung, which can be used to estimate cell type fractions of endothelial cells, epithelial cells, granulocytes, lymphocytes, macrophages, monocytes and stromal cells in Lung tissue with EpiSCORE framework.Lung_Expref.csvA scRNAseq expression reference for Lung. Each row is a marker gene (in gene symbol) and each column is a cell type. For each marker gene, the value of the reference matrix is the median expression level for each type of cells in scRNAseq data.Lung_Mref.csvA DNAm reference for Lung. Each row is a marker gene (in entrezID) and each column is a cell type. The last column is the weight for each marker. The value of the matrix is the imputed DNAm level from expression reference.

本数据集包含1788个标志物的表达参考集与261个标志物的DNA甲基化（DNA methylation，缩写DNAm）肺组织参考集，可依托EpiSCORE框架对肺组织内皮细胞、上皮细胞、粒细胞、淋巴细胞、巨噬细胞、单核细胞及基质细胞的细胞类型占比进行估算。
Lung_Expref.csv：肺组织单细胞RNA测序（single-cell RNA sequencing，缩写scRNAseq）表达参考集。该矩阵的行代表以基因符号（gene symbol）标注的标志物基因，列代表细胞类型；对于每个标志物基因，参考矩阵的取值为对应细胞类型在scRNAseq数据中的中位表达水平。
Lung_Mref.csv：肺组织DNA甲基化参考集。该矩阵的行代表以Entrez ID标注的标志物基因，列代表细胞类型，最后一列为每个标志物的权重；矩阵的取值为从表达参考集推算得到的估算DNA甲基化水平。