Although most patients with multiple myeloma respond to treatment initially, therapy resistance develops almost invariably and only a subset of patients show durable responses to immunomodulatory (IMi

NIAID Data Ecosystem40

A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane. A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane

乳腺癌激素治疗

受体信号传导

This work show that hormone action, which is assumed to act via binding to intracellular nuclear receptors, can also trigger a global cellular response acting on membrane bound receptors. We designed

NIAID Data Ecosystem30

Murine Gammaherpesvirus M2 Protein Induction of IRF4 via the NFAT Pathway Leads to IL-10 Expression in B Cells

疱疹病毒基因调控

细胞信号通路

Reactivation of the gammaherpesviruses Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV) and murine gammaherpesvirus 68 (MHV68) from latently infected B cells has been linked to

Figshare2016-01-18 更新50

Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles

毛囊发育遗传调控

细胞信号通路

Planar cell polarity (PCP) signaling controls the global orientation of surface structures, such as hairs and bristles, in both vertebrates and invertebrates. In Frizzled6-/- (Fz6-/-) mice, hair folli

Figshare2016-01-15 更新40

Combinatorial effects of estrogen with progestogens or androgen in the breast cancer cell line ZR-75-1

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