Tandem Michael Addition/Cyclization Reaction of 2,3-Allenoates with Organozincs: Facile Synthesis of Isocoumarins

A series of isocoumarin derivatives have been synthesized via the reaction of 2-(o-(methoxycarbonyl)phenyl)-2,3-allenoates with organozincs in CH2Cl2 at room temperature (for dialkylzinc) or 100 °C (for Ph2Zn) through a tandem Michael addition/intramolecular cyclization process.

本研究通过串联迈克尔加成/分子内环化反应路径，以二氯甲烷（CH₂Cl₂）为反应溶剂，对于二烷基锌试剂采用室温反应条件，对于二苯基锌（Ph₂Zn）则采用100 ℃的反应条件，由2-(邻-甲氧羰基苯基)-2,3-联烯酸酯与有机锌试剂反应合成了一系列异香豆素衍生物。