Table_1_The increasing incidence and high body mass index-related burden of gallbladder and biliary diseases–A results from global burden of disease study 2019.pdf

BackgroundGallbladder and biliary diseases are common gastrointestinal conditions associated with huge socioeconomic costs and are considered risk factors for cardiovascular diseases and digestive system cancers. The prevalence and incidence of gallbladder and biliary diseases have not received enough attention from 1990 to 2019. Several non-communicable diseases were associated with the incidence of gallbladder and biliary diseases. It is necessary to clarify the change in the incidence and disability burden of gallbladder and biliary diseases worldwide.
MethodsData on high body mass index (BMI)-related disease burden and incidence, years of life lost prematurely, and years lived with disability (YLDs) due to gallbladder and biliary diseases were obtained from the Global Burden of Disease 2019. The estimated annual percentage change was calculated to qualify the gallbladder and biliary disease burden change.
ResultsThe global age-standardized incidence rate has increased from 585.35 per 100,000 (95% UI: 506.05–679.86) in 1990 to 634.32 per 100,000 (95% UI: 540.21–742.93) in 2019. And the increase in incidence was positively correlated with rising high BMI-related summary exposure value. The high BMI-related YLDs of gallbladder and biliary diseases have increased worldwide over time. Globally, the 25–49 age group suffered a rapid rise in incidence and high BMI attributable to the YLDs rate of gallbladder and biliary diseases.
ConclusionThe global incidence and high BMI-related YLDs of gallbladder and biliary diseases remain prominent to increase over the past 30 years. Notably, the incidence and high BMI-related YLDs among people aged 25–49 years have rapidly increased over time. Therefore, high BMI should be emphasized in strategic priorities for controlling gallbladder and biliary diseases.

背景 胆囊与胆道疾病是一类常见的胃肠道疾病，不仅造成巨额社会经济负担，同时也是心血管疾病与消化系统恶性肿瘤的危险因素。1990年至2019年间，胆囊与胆道疾病的患病率与发病率未得到足够重视。已有研究显示多种非传染性疾病与胆囊与胆道疾病的发病相关，因此有必要明确全球范围内胆囊与胆道疾病的发病率变化与残疾负担情况。
方法 本研究从2019年全球疾病负担研究（Global Burden of Disease 2019）中获取胆囊与胆道疾病相关的高体质指数（body mass index, BMI）疾病负担、发病率、早死寿命损失年以及伤残损失健康寿命年（years lived with disability, YLDs）数据，并通过计算估计年度百分比变化，以量化胆囊与胆道疾病负担的变化趋势。
结果 全球年龄标化发病率（age-standardized incidence rate）已从1990年的585.35/10万（95%不确定区间：506.05~679.86）上升至2019年的634.32/10万（95%不确定区间：540.21~742.93）。发病率的上升与高BMI相关总暴露值的升高呈正相关。全球范围内，胆囊与胆道疾病相关的高BMI归因YLDs随时间推移呈增长趋势。其中，25~49岁年龄组的胆囊与胆道疾病发病率及高BMI归因的伤残损失健康寿命年率均出现快速上升。
结论 过去30年间，全球胆囊与胆道疾病的发病率及高BMI相关YLDs仍呈显著上升趋势。值得注意的是，25~49岁人群的胆囊与胆道疾病发病率及高BMI相关YLDs随时间快速增长。因此，在胆囊与胆道疾病防控的战略重点中，应高度重视高BMI这一危险因素。