Hypoxylon pulicicidum strain:MF5954 Genome sequencing and assembly. Hypoxylon pulicicidum strain:MF5954

Hypoxylon pulicicidum, MF 5954, ATCC 74245 is an endophytic fungus first isolated from a woody plant (Bontia daphnoides) in Hawaii, USA and originally identified as Nodulisporium sp. H. pulicicidum is known for its production of nodulisporic acids, a group of bioactive indole diterpene secondary metabolites derived from emindole SB. Nodulisporic acid A is of particular significance because it exhibits highly potent insecticidal activity. The genome sequence of this fungus was sequenced to facilitate identification and investigation of the genes required for biosynthesis of nodulisporic acids.

淡色炭角菌（Hypoxylon pulicicidum）菌株MF 5954、ATCC 74245是一种内生真菌（endophytic fungus），该菌株首次从美国夏威夷的木本植物（Bontia daphnoides）中分离得到，最初被鉴定为节菱孢菌属（Nodulisporium）未定种。该菌以合成节菱孢酸类（nodulisporic acids）物质而闻名，这类具有生物活性的吲哚二萜类次生代谢产物（indole diterpene secondary metabolites）均以emindole SB为生物合成前体。其中节菱孢酸A（nodulisporic acid A）具有特殊研究价值，因其展现出极高的杀虫活性。为了便于鉴定并探究节菱孢酸生物合成所需的相关基因，研究人员完成了该菌株的基因组测序。