Crystal Structure of the N-terminal domain of an HSP90 from Plasmodium Falciparum, PFL1070c in the presence of a thienopyrimidine derivative

Crystal Structure of the N-terminal domain of an HSP90 from Plasmodium Falciparum, PFL1070c in the presence of a thienopyrimidine derivative Descriptor: 2-amino-4-{2,4-dichloro-5-[2-(diethylamino)ethoxy]phenyl}-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide, Endoplasmin homolog, SULFATE ION Authors: Wernimont, A.K, Tempel, W, Hutchinson, A, Weadge, J, Cossar, D, MacKenzie, F, Vedadi, M, Senisterra, G, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Wyatt, P.G, Fairlamb, A.H, MacKenzie, C, Ferguson, M.A.J, Hui, R, Pizarro, J.C, Hills, T, Structural Genomics Consortium (SGC) Deposit date: 2010-10-26 Release date: 2010-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Crystal Structure of the N-terminal domain of an HSP90 from Plasmodium Falciparum, PFL1070c in the presence of a thienopyrimidine derivative To be Published

恶性疟原虫（Plasmodium Falciparum）来源的热休克蛋白90（HSP90）PFL1070c的N端结构域在结合噻吩并嘧啶衍生物条件下的晶体结构
描述符：2-氨基-4-{2,4-二氯-5-[2-(二乙氨基)乙氧基]苯基}-N-乙基噻吩并[2,3-d]嘧啶-6-甲酰胺、内质网蛋白同源物、硫酸根离子
作者：Wernimont, A.K.、Tempel, W.、Hutchinson, A.、Weadge, J.、Cossar, D.、MacKenzie, F.、Vedadi, M.、Senisterra, G.、Arrowsmith, C.H.、Edwards, A.M.、Bountra, C.、Weigelt, J.、Wyatt, P.G.、Fairlamb, A.H.、MacKenzie, C.、Ferguson, M.A.J.、Hui, R.、Pizarro, J.C.、Hills, T.、结构基因组学联盟（SGC）
沉积日期：2010-10-26
发布日期：2010-11-17
最后修改日期：2023-09-06
实验方法：X射线衍射（分辨率2.75 Å）
引用文献：恶性疟原虫来源的热休克蛋白90（HSP90）PFL1070c的N端结构域结合噻吩并嘧啶衍生物的晶体结构，待发表