Serpentine: a flexible 2D binning method for differential Hi-C analysis

We present a fast, flexible procedure, called Serpentine, operating on raw data, that considers the contacts in each region of a contact map. Binning is performed only when necessary on noisy regions, preserving informative ones. This results in high-quality, low-noise contact maps that can be conveniently visualized for rigorous comparative analyses.

本研究提出一种名为Serpentine的快速灵活流程，可直接处理原始数据，且可针对接触图谱（contact map）各区域内的接触关联进行分析。该流程仅在存在噪声的区域执行分箱操作，保留信息丰富的区域不予处理，最终可生成高质量、低噪声的接触图谱，便于可视化以开展严谨的对比分析。