Crystal structure of holo-H44A mutant of Hydroxy ketone aldolase (SwHKA) from Sphingomonas wittichii RW1, in complex with Hydroxypyruvate

Crystal structure of holo-H44A mutant of Hydroxy ketone aldolase (SwHKA) from Sphingomonas wittichii RW1, in complex with Hydroxypyruvate Descriptor: 3-HYDROXYPYRUVIC ACID, BROMIDE ION, HpcH/HpaI aldolase, ... Authors: Laustsen, J, Justo, I, Marsden, S.R, Hanefeld, U, Bento, I. Deposit date: 2021-04-09 Release date: 2022-11-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Substrate Induced Movement of the Metal Cofactor between Active and Resting State. Angew.Chem.Int.Ed.Engl., 61, 2022

施氏鞘氨醇单胞菌RW1（Sphingomonas wittichii RW1）来源的羟基酮醛缩酶（Hydroxy ketone aldolase, SwHKA）的全酶型H44A突变体，与羟基丙酮酸（Hydroxypyruvate，标识为3-羟基丙酮酸（3-HYDROXYPYRUVIC ACID））、溴离子（BROMIDE ION）及HpcH/HpaI醛缩酶（HpcH/HpaI aldolase）等形成的复合物的晶体结构。作者：Laustsen, J、Justo, I、Marsden, S.R、Hanefeld, U、Bento, I。沉积日期：2021-04-09；发布日期：2022-11-16；最后修改日期：2024-01-31。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.95埃（1.95 Å））。引用文献：《底物诱导金属辅因子在活性态与静息态间的移动》，《德国应用化学（Angew.Chem.Int.Ed.Engl.）》，第61卷，2022年。