Data from: Integrating pheromonal and spatial information in the amygdalo-hippocampal network. Villafranca-Faus et al. 2021

The local field potential (LFP) of the dorsal hippocampus (CA1) and cortical amygdala (PMCo) of mice, under head-fix recording and inmersed on a virtual environtmernt.

Paper Abstract: 
Vomeronasal information is critical in mice for territorial behavior. Consequently, learning the territorial spatial structure should incorporate the vomeronasal signals indicating individual identity into the hippocampal cognitive map. In this work we show in mice that navigating a virtual environment induces synchronic activity, with causality in both directionalities, between the vomeronasal amygdala and the dorsal CA1 of the hippocampus in the theta frequency range. The detection of urine stimuli induces synaptic plasticity in the vomeronasal pathway and the dorsal hippocampus, even in animals with experimentally induced anosmia. In the dorsal hippocampus, this plasticity is associated with the overexpression of pAKT and pGSK3β. An amygdalo-entorhino-hippocampal circuit likely underlies this effect of pheromonal information on hippocampal learning. This circuit likely constitutes the neural substrate of territorial behavior in mice, and it allows the integration of social and spatial information.

本数据集包含小鼠背侧海马（CA1区）与皮层杏仁核（PMCo）的局部场电位（local field potential, LFP），数据采集于头部固定记录范式，且小鼠处于虚拟环境中。

论文摘要：
犁鼻信息对小鼠的领地行为具有关键作用。据此，对领地空间结构的学习过程，应当将指示个体身份的犁鼻信号整合至海马认知地图中。本研究通过小鼠实验证实，在θ频段范围内，小鼠在虚拟环境中导航时，犁鼻杏仁核与海马背侧CA1区之间会产生双向因果关联的同步活动。尿液刺激可在犁鼻通路与背侧海马中诱导突触可塑性，即使在实验诱导嗅觉缺失的动物中亦是如此。在背侧海马内，该可塑性与pAKT及pGSK3β的过表达密切相关。杏仁核-内嗅皮层-海马环路可能介导了信息素信息对海马学习的上述调控效应，该环路或是小鼠领地行为的神经底物，并可实现社交信息与空间信息的整合。