Acute Kidney Injury by SARS-CoV-2 virus in patients with COVID-19: an integrative review

ABSTRACT Objective: to assess scientific evidence on SARS-CoV-2 Acute Kidney Injury in patients with COVID-19. Methods: an integrative review, with adoption of PICO strategy and classification of the level of evidence, carried out on April 10, 2020 in the PubMed database, of articles available between December 2019 and April 2020. Results: the sample consisted of six original, five observational and one experimental articles. Observational studies addressed the clinical findings of patients with COVID-19 and association between kidney damage, infection, and morbidity-mortality. Conclusion: the studies addressed the mechanism of intracellular infection of SARS-CoV-2, its cytopathic effects on kidney cells and incidence of acute kidney injury in patients infected with SARS-CoV-2. Acute kidney injury is associated with increased mortality and morbidity in these patients. This review realizes the need for new research that can mention kidney care to patients with COVID-19.

摘要
研究目的：评估新型冠状病毒肺炎（COVID-19）患者合并严重急性呼吸综合征冠状病毒2（SARS-CoV-2）相关急性肾损伤（Acute Kidney Injury）的科学证据。
研究方法：本研究为整合性综述，采用PICO（Population, Intervention, Comparison, Outcome）策略并对证据等级进行分类，于2020年4月10日在PubMed数据库中检索2019年12月至2020年4月期间发表的相关文章。
研究结果：最终纳入6篇原创性研究，其中5篇为观察性研究，1篇为实验性研究。观察性研究探讨了COVID-19患者的临床特征，以及肾损伤、病毒感染与发病-死亡结局之间的关联。
研究结论：现有研究阐明了SARS-CoV-2的细胞内感染机制、其对肾细胞的细胞病变效应，以及SARS-CoV-2感染者急性肾损伤的发生率。急性肾损伤与此类患者的死亡率及并发症发生率升高显著相关。本综述指出，亟需开展更多相关研究，以明确针对COVID-19患者的肾脏护理方案。