Chronic sleep fragmentation reduces left ventricular contractile function and alters gene expression related to innate immune response and circadian rhythm in the mouse heart

Purpose: The purpose of this study was to comprehensively identify the gene expression changes that occur after chronic sleep fragmentation. Method: We conducted total microarray analysis of the heart in mice following 5 weeks of sleep fragmentation. Results: The microarray analysis revealed significant and dramatic gene expression changes in the mouse heart as a result of chronic sleep fragmentation. Conclusion: This study provides valuable insights into the biological impact of chronic sleep fragmentation, shedding light on the molecular mechanisms involved. Microarray analysis was conducted on 21-week-old female C57BL/6N mice who were subjected to either 5 weeks of sleep fragmentation or left undisturbed.

研究目的：本研究旨在全面识别慢性睡眠片段化后发生的基因表达变化。
研究方法：我们对经过5周慢性睡眠片段化处理的小鼠心脏开展了全基因组微阵列（microarray）分析。
研究结果：微阵列分析结果显示，慢性睡眠片段化会导致小鼠心脏出现显著且剧烈的基因表达变化。
研究结论：本研究为慢性睡眠片段化的生物学影响提供了宝贵见解，阐明了其涉及的分子机制。本次研究以21周龄雌性C57BL/6N小鼠为实验对象，对其心脏进行微阵列分析，这些小鼠被分为两组：一组接受5周慢性睡眠片段化处理，另一组则保持无干扰状态。