Table_1_Decreased Serum Brain-Derived Neurotrophic Factor in Poststroke Depression: A Systematic Review and Meta-Analysis.DOCX

BackgroundsThere were conflicting results on the comparison of brain-derived neurotrophic factor (BDNF) levels between poststroke depression (PSD) patients and stroke patients without PSD among previous studies. Thus, we conducted this systemic review and meta-analysis to explore the alteration of serum BDNF levels in PSD.
MethodsThis study included articles from the Web of Science and PubMed databases that were published before December 2021. STATA 12.0 software was used to compute the standardized mean difference (SMD) and 95% confidence interval (CI) regarding the comparison of serum BDNF in PSD and stroke patients without PSD.
ResultsWe collected the mean value and standard deviation (SD) of serum BDNF in PSD and stroke patients without PSD from six studies (PSD: n = 268, stroke patients without PSD: n = 425). The present meta-analysis showed decreased serum BDNF level in patients with PSD, compared to stroke patients without PSD with a random-effects model (mean value of BDNF level [PSD vs. stroke patients without PSD]: 14.106 vs. 17.995 ng/ml; SMD = –1.578; 95% CI: –2.820, –0.337; I2 = 97.8%, p-value for Q test < 0.001).
ConclusionBrain-derived neurotrophic factor may work as a potential biomarker to predict the risk of PSD among stroke survivors. More large-sample clinical trials exploring the alteration of serum BDNF levels in PSD among stroke patients need to be conducted to verify this result.

背景：既往研究在卒中后抑郁（poststroke depression, PSD）患者与非抑郁卒中患者的脑源性神经营养因子（brain-derived neurotrophic factor, BDNF）水平比较中存在结果不一致的情况。为此，本研究开展本次系统评价与Meta分析，以探讨卒中后抑郁患者血清BDNF水平的变化情况。
方法：本研究检索了2021年12月之前发表于Web of Science与PubMed数据库的相关文献。采用STATA 12.0软件计算卒中后抑郁患者与非抑郁卒中患者血清BDNF水平比较的标准化均数差（standardized mean difference, SMD）及95%置信区间（95% confidence interval, CI）。
结果：本研究从6项研究中提取了卒中后抑郁患者（PSD组：n = 268）与非抑郁卒中患者（n = 425）的血清BDNF均值与标准差（standard deviation, SD）。本次Meta分析采用随机效应模型，结果显示，相较于非抑郁卒中患者，卒中后抑郁患者的血清BDNF水平显著降低：PSD组与非抑郁卒中组的BDNF水平均值分别为14.106 ng/ml与17.995 ng/ml；标准化均数差为–1.578，95%置信区间为–2.820至–0.337；I² = 97.8%，Q检验P值< 0.001。
结论：脑源性神经营养因子或可作为预测卒中幸存者发生卒中后抑郁风险的潜在生物标志物。未来仍需开展大样本临床研究，进一步探讨卒中患者血清BDNF水平在卒中后抑郁中的变化，以验证本次研究结果。