Structure of J-PKAc chimera complexed with Aplithianine A
收藏Protein Data Bank Japan2024-11-20 更新2026-04-19 收录
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Structure of J-PKAc chimera complexed with Aplithianine A Descriptor: 6-[(6M)-6-(1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-9H-purine, DnaJ homolog subfamily B member 1, cAMP-dependent protein kinase catalytic subunit alpha, ... Authors: Du, L, Wilson, B.A.P, Li, N, Dalilian, M, Wang, D, Martinez Fiesco, J.A, Smith, E.A, Wamiru, A, Goncharova, E.I, Zhang, P, O'Keefe, B.R. Deposit date: 2022-12-05 Release date: 2023-10-18 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases. J.Nat.Prod., 86, 2023
与Aplithianine A结合的J-PKAc嵌合体晶体结构
描述项：6-[(6M)-6-(1-甲基-1H-咪唑-5-基)-2,3-二氢-4H-1,4-噻嗪-4-基]-9H-嘌呤、DnaJ同源物B亚家族成员1（DnaJ homolog subfamily B member 1）、环腺苷酸依赖性蛋白激酶催化亚基α（cAMP-dependent protein kinase catalytic subunit alpha）等……
作者：Du, L、Wilson, B.A.P、Li, N、Dalilian, M、Wang, D、Martinez Fiesco, J.A、Smith, E.A、Wamiru, A、Goncharova, E.I、Zhang, P、O'Keefe, B.R.
提交日期：2022-12-05；发布日期：2023-10-18；最后修改日期：2024-11-20
检测方法：X射线衍射（2.34 埃）
引用文献：《一种天然来源蛋白激酶抑制剂的发现与合成：可选择性抑制不同类别丝氨酸/苏氨酸激酶》，《天然产物杂志（J.Nat.Prod.）》，第86卷，2023年
创建时间：
2022-12-05
