Data Sheet 9_Burden analysis of diabetic nephropathy caused by excessive intake of sugar-sweetened beverages in high and low SDI regions.csv

ObjectiveThe Global Burden of Disease Study (GBD) 2019 reveals an increasing prevalence of diabetic nephropathy caused by excessive intake of sugar-sweetened beverages in high and low SDI regions from 1990 to 2021.
MethodsThis study comprehensively analyzed the burden of DN caused by SSBs in high and low SDI regions from 1990 to 2021 and projected the trends until 2040 using ARIMA models.
ResultsThe results revealed distinct patterns and trends in age-standardized rates of deaths, DALYs, YLDs, and YLLs between the two regions. In high SDI regions, the age-standardized rates of deaths, DALYs, YLDs, and YLLs exhibited a consistent upward trend from 1990 (0.044, 1.425, 0.537, 0.888 per 100,000) to 2021 (0.096, 2.284, 0.67, 2.154 per 100,000). Projections for the age-standardized rates in high SDI regions from 2021 to 2040 indicate that these upward trends will persist, with deaths, DALYs, YLDs, and YLLs further increasing to 0.127, 3.629, 1.070, and 2.861 per 100,000. Conversely, low SDI regions displayed different trends. Although the age-standardized rates of deaths, DALYs, YLDs, and YLLs also increased from 1990 (0.018, 0.488, 0.071, 0.417 per 100,000) to 2021 (0.020, 0.522, 0.081, 0.441 per 100,000), the rate of increase was relatively slower compared to high SDI regions. Projections for the age-standardized rates in low SDI regions from 2021 to 2040 suggest that these upward trends will continue, with deaths, DALYs, YLDs, and YLLs further increasing to 0.016, 0.498, 0.105, and 0.398 per 100,000.
ConclusionThis study provides a comprehensive analysis of the burden of type 2 diabetes nephropathy caused by excessive intake of sugar-sweetened beverages in high and low SDI regions. The results revealed distinct patterns and trends in age-standardized rates of deaths, DALYs, YLDs, and YLLs between the two regions.

研究背景：2019年全球疾病负担研究（Global Burden of Disease Study, GBD）显示，1990年至2021年，高、低社会人口学指数（Socio-demographic Index, SDI）地区中，因过量摄入含糖饮料（sugar-sweetened beverages, SSBs）引发的糖尿病肾病（diabetic nephropathy, DN）患病率呈持续上升趋势。研究方法：本研究全面分析了1990年至2021年高、低SDI地区中，SSBs所致糖尿病肾病的疾病负担，并采用自回归积分滑动平均（AutoRegressive Integrated Moving Average, ARIMA）模型对2040年之前的疾病负担趋势进行预测。研究结果：本研究揭示了两类地区在死亡率、伤残调整寿命年（Disability-Adjusted Life Years, DALYs）、伤残损失健康寿命年（Years Lived with Disability, YLDs）及早死损失寿命年（Years of Life Lost, YLLs）的年龄标化率上存在显著不同的模式与趋势。在高SDI地区，上述四项指标的年龄标化率从1990年的每10万人0.044、1.425、0.537、0.888，持续上升至2021年的每10万人0.096、2.284、0.67、2.154。对2021年至2040年高SDI地区年龄标化率的预测显示，上述上升趋势将持续，死亡率、DALYs、YLDs及YLLs将进一步分别升至每10万人0.127、3.629、1.070、2.861。与之相反，低SDI地区呈现出不同的趋势。尽管该地区上述四项指标的年龄标化率同样从1990年的每10万人0.018、0.488、0.071、0.417，上升至2021年的每10万人0.020、0.522、0.081、0.441，但增幅相较于高SDI地区相对平缓。对2021年至2040年低SDI地区年龄标化率的预测显示，上述上升趋势将持续，死亡率、DALYs、YLDs及YLLs将分别进一步升至每10万人0.016、0.498、0.105、0.398。研究结论：本研究全面分析了1990年至2021年高、低SDI地区中，过量摄入SSBs所致2型糖尿病肾病的疾病负担。研究结果显示，两类地区在死亡率、DALYs、YLDs及YLLs的年龄标化率上存在显著不同的模式与趋势。