Total Synthesis of (−)-Nodulisporic Acid D

A convergent total synthesis of the architecturally complex indole diterpenoid (−)-nodulisporic acid D has been achieved. Key synthetic transformations include vicinal difunctionalization of an advanced α,β-unsaturated aldehyde to form the E,F-trans-fused 5,6-ring system of the eastern hemisphere and a cascade cross-coupling/indolization protocol leading to the CDE multisubstituted indole core.本研究实现了结构复杂的吲哚二萜类化合物(-)-结节孢酸D的汇聚式全合成。关键合成转化包括：对高级α,β-不饱和醛进行邻位双官能团化反应，构建东半片段的E、F环反式稠合5,6元环体系；以及采用级联交叉偶联/吲哚化反应策略，构筑CDE位多取代吲哚母核。