Tandem Reactions of 1,2-Allenic Ketones Leading to Substituted Benzenes and α,β-Unsaturated Nitriles

One-pot double Michael addition/intramolecular aldol reaction/decarboxylation of 1,2-allenic ketones with cyanoacetate offers an efficient and convenient approach to highly functionalized benzenes. With 2-substituted cyanoacetates, the reaction proceeds via a different tandem process to afford α,β-unsaturated nitriles effectively.

1,2-联烯酮与氰乙酸酯的一锅法双迈克尔加成/分子内羟醛缩合/脱羧反应，为高官能化苯类化合物的合成提供了高效便捷的途径。当以2-取代氰乙酸酯为底物时，该反应会经由不同的串联过程，高效生成α,β-不饱和腈类化合物。