Efficacy of a novel endoscopically deliverable muco-adhesive hemostatic powder in an acute gastric bleeding porcine model

This study investigated the effectiveness of new hemostatic adhesive powder (UI-EWD) in a swine mode of acute gastric bleeding. Gastric ulcer bleeding was induced endoscopically at two locations in each of eight heparinized mini-pigs. UI-EWD and saline were sprayed endoscopically in the experimental (n = 5) and control groups (n = 3), respectively. The hemostatic effect and hydrogel persistence on ulcers were periodically evaluated endoscopically. Initial hemostasis was achieved successfully in all lesions in the experimental group. Follow-up endoscopy showed minor delayed bleeding in 10% at 6 hours in the experimental group, whereas re-bleeding was observed in 50% at 6 hours in the control group. UI-EWD gel persisted at 90%, 80%, and 50% of ulcer bases at 6, 18, and 42 hours post-application, respectively. This study suggests that muco-adhesive UI-EWD may be effective in the endoscopic treatment of active ulcer bleeding.

本研究针对新型止血粘合剂粉末（hemostatic adhesive powder，UI-EWD）在急性胃出血猪模型中的应用有效性展开探究。研究对8只肝素化小型猪分别经内镜于两处位置诱发胃溃疡出血。实验组（n=5）与对照组（n=3）分别经内镜喷涂UI-EWD与生理盐水。研究人员定期通过内镜评估止血效果及水凝胶在溃疡部位的留存情况。实验组所有病灶均成功实现初始止血。随访内镜检查结果显示，实验组给药后6小时内有10%的病灶出现轻微延迟性出血，而对照组同期再出血率达50%。UI-EWD水凝胶在给药后6、18及42小时，分别留存于90%、80%及50%的溃疡基底区域。本研究表明，黏膜黏附性UI-EWD可有效应用于活动性溃疡出血的内镜治疗。