Comparisons of serum I2S pharmacokinetic parameters after 4 different idursulfase treatments.

AUCinf, area under the concentration-time curve extrapolated to infinity; AUC0-t, area under the concentration-time curve from time 0 to the last sampling time; CL, total clearance; Cmax, maximum observed concentration; I2S, iduronate-2-sulfatase; IT-L, intrathecal lumbar; IV, intravenous; MRTinf, mean residual time derived from time 0 to infinity; na, not available; SD, standard deviation; t½, terminal half-life; Tmax, time of occurrence of Cmax; Vss, volume of distribution at steady state; Vz, volume of distribution during terminal phase; λZ, apparent terminal rate constant.
aUnits were ml/kg for IV dosing and ml for IT-L
bn = 6
cn = 7
dUnits were ml/h/kg for IV dosing and ml/h for IT-L.
Comparisons of serum I2S pharmacokinetic parameters after 4 different idursulfase treatments.

AUCinf：无穷远外推浓度-时间曲线下面积（AUCinf）；AUC0-t：0至末次采样时间点的浓度-时间曲线下面积（AUC0-t）；CL：总清除率（CL）；Cmax：观测到的最大血药浓度（Cmax）；I2S：艾杜糖醛酸-2-硫酸酯酶（iduronate-2-sulfatase，I2S）；IT-L：腰椎鞘内给药（intrathecal lumbar，IT-L）；IV：静脉给药（intravenous，IV）；MRTinf：外推至无穷远的平均残留时间（MRTinf）；na：不可用（not available，na）；SD：标准差（standard deviation，SD）；t½：终末半衰期（terminal half-life，t½）；Tmax：达峰时间（time of occurrence of Cmax，Tmax）；Vss：稳态表观分布容积（volume of distribution at steady state，Vss）；Vz：终末相分布容积（volume of distribution during terminal phase，Vz）；λZ：表观终末速率常数（apparent terminal rate constant，λZ）。
a 静脉给药（IV）组单位为ml/kg，腰椎鞘内给药（IT-L）组单位为ml；
b n=6；
c n=7；
d 静脉给药（IV）组单位为ml/h/kg，腰椎鞘内给药（IT-L）组单位为ml/h。
4种艾杜硫酸酶（idursulfase）治疗方案后血清I2S药代动力学参数的比较。