Effect of inhibition of PI3-Kinase p110alpha on saturated fatty acid-induced gene expression alterations in murine 3T3-L1 adipocytes

Gene expression pattern in murine 3T3-L1 adipocytes treated with saturated fatty acid (palmitate) in the presence or absence of PI3K p110alpha-selective inhibitor A66. Overall design: Differentiated 3T3-L1 adipocytes were treated with p110alpha inhibitor (A66) or palmitate or a combination or both. Gene expression alterations were compared to untreated adipocytes.

本数据集涵盖在存在或不存在磷脂酰肌醇3-激酶（PI3K）p110α选择性抑制剂A66的条件下，经饱和脂肪酸（棕榈酸，palmitate）处理的小鼠3T3-L1脂肪细胞的基因表达模式。实验设计概述：将分化成熟的3T3-L1脂肪细胞分别以p110α抑制剂（A66）、棕榈酸单独处理，或二者联合处理，并与未处理的脂肪细胞进行比对，分析其基因表达变化。