Inhibition of BRD4 Rescues Cardiac phenotype in Myocyte-Specific Lamin A/C Null Mice

Deletion of Lmna, encoding nuclear membrane protein LMNA, specifically in mouse cardiac myocytes activates BRD4 and leads to heart failure, arrhythmias, myocardial fibrosis, apoptosis, and premature death, which were partially rescued upon inhibition of BRD4. RNA-seq from Cardiac myocytes from 4 control (WT) and 4 Myh6-cre:LmnaF/F vehicle treated and 4 Myh6-cre:LmnaF/F JQ1 treated

特异性敲除小鼠心肌细胞中编码核膜蛋白LMNA的Lmna基因，可激活溴结构域蛋白4（BRD4），进而引发心力衰竭、心律失常、心肌纤维化、细胞凋亡及过早死亡；该病理表型可通过抑制BRD4得到部分挽救。本数据集的转录组测序（RNA-seq）样本来源于4只野生型（WT）对照小鼠的心肌细胞，以及4只经载体处理的Myh6-cre:LmnaF/F小鼠和4只经JQ1处理的Myh6-cre:LmnaF/F小鼠的心肌细胞。