3D cyto- and receptor architectonic map of macaque somatosensory area 1 (v1.0)

A multimodal analysis of the macaque somatosensory cortex was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This project involved a quantitative and statistically testable approach to the analysis of cyto-/myeloarchitecture in the macaque monkey somatosensory cortex, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 14 different neurotransmitter receptors. The borders of the identified areas were traced onto the macaque stereotaxic space provided by the MEBRAINS and Yerkes 19 templates.

We provide here for the first time a map of area 1 of the macaque monkey brain integrating cyto-, myelo- and receptor architectonic features in stereotaxic space. It constitutes a valuable resource for the analysis of functional experiments with non-human primates, and provides crucial data for modeling approaches with realistic synaptic dynamics.

为构建整合并调和先前发表图谱间差异的3D图谱（3D atlas），我们对猕猴体感皮层（somatosensory cortex）开展了多模态分析（multimodal analysis）。本项目采用定量且可统计检验的方法分析猕猴体感皮层的细胞/髓鞘结构（cyto-/myeloarchitecture），并结合体外定量受体放射自显影分析（in vitro quantitative receptor autoradiographic analysis）研究14种不同神经递质受体（neurotransmitter receptors）的区域及层状分布模式。识别出的脑区边界被映射至MEBRAINS与Yerkes 19模板提供的猕猴立体定向空间（stereotaxic space）中。

我们首次在此提供猕猴大脑1区的图谱，该图谱整合了立体定向空间中细胞、髓鞘及受体的结构特征（architectonic features）。此图谱为非人灵长类动物（non-human primates）功能实验分析提供了宝贵资源，也为具有真实突触动力学（synaptic dynamics）的建模方法提供了关键数据。