Clinical Significance of Cys-C and hs-CRP in Coronary Heart Disease Patients Undergoing Percutaneous Coronary Intervention

Abstract Objective: To investigate the clinical significance of serum cystatin C (Cys-C) and high-sensitivity C-reactive protein (hs-CRP) in coronary heart disease (CHD) patients undergoing percutaneous coronary intervention (PCI). Methods: One hundred and twenty-eight CHD patients were divided into drug treatment (56 cases) and PCI treatment (72 cases) groups, receiving conventional drug treatment and PCI plus conventional drug treatment, respectively. At admission time and 4 weeks after treatment, the left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter, and left ventricular end systolic diameter were measured. At admission time and 24h, 72h, 1 week, and 4 weeks after treatment, the serum levels of Cys-C and hs-CRP were determined. Results: After 4 weeks of treatment, LVEF in the PCI treatment group was significantly higher than that before treatment (P<0.01) and it was significantly higher than in the drug treatment group at the same time (P<0.01). Cys-C and hs-CRP level in the PCI treatment group were significantly higher than in the drug treatment group 72h and 1 week after treatment (P<0.05 or P<0.01), respectively, but they were significantly lower than in the drug treatment group 4 weeks after treatment (P<0.01). There were obvious interaction effects between grouping factor and time factor in Cys-C (F=3.62, P<0.05) and hs-CRP (F=17.85, P<0.01). Conclusion: Serum levels of Cys-C and hs-CRP are closely related to the heart function in CHD patients undergoing PCI, and they may be used for predicting the outcome of PCI.

摘要 目的：探讨血清胱抑素C（serum cystatin C, Cys-C）与高敏C反应蛋白（high-sensitivity C-reactive protein, hs-CRP）在接受经皮冠状动脉介入治疗（percutaneous coronary intervention, PCI）的冠心病（coronary heart disease, CHD）患者中的临床意义。方法：纳入128例冠心病患者，分为药物治疗组（56例）与PCI治疗组（72例），分别接受常规药物治疗以及PCI联合常规药物治疗。分别于入院时及治疗4周后，检测左心室射血分数（left ventricular ejection fraction, LVEF）、左心室舒张末期内径与左心室收缩末期内径。于入院时、治疗后24h、72h、1周及4周，测定血清Cys-C与hs-CRP水平。结果：治疗4周后，PCI治疗组左心室射血分数较治疗前显著升高（P<0.01），且同期显著高于药物治疗组（P<0.01）。PCI治疗组在治疗后72h及1周时的Cys-C与hs-CRP水平分别显著高于药物治疗组（P<0.05或P<0.01），但于治疗4周时显著低于药物治疗组（P<0.01）。Cys-C（F=3.62，P<0.05）与hs-CRP（F=17.85，P<0.01）的分组因素与时间因素均存在显著交互效应。结论：血清Cys-C与hs-CRP水平与接受PCI治疗的冠心病患者的心功能密切相关，或可用于预测PCI治疗结局。