Supplementary Material for: Characteristics and graft outcomes of kidney transplant candidates with enteric risk factors and elevated plasma oxalate levels

Introduction: This study describes patient characteristics and examines graft function of kidney transplant recipients (without primary hyperoxaluria) with elevated plasma oxalate (POx) and enteric risk factors prior to transplant at our institution. Methods: Kidney transplant recipients between 2012 to 2020 with elevated POx at the time of kidney transplant evaluation were included. A matched control cohort was gathered using patient/donor age, living/deceased donor type, panel reactive antibody (PRA), kidney donor profile index (KDPI), and human leukocyte antigen (HLA) mismatch as matching variables. Graft function at 1 year and at last follow-up was reported. Results: A total of 106 patients with elevated POx were identified. A third of the patients had Roux-en-Y gastric bypass, a third had other enteric risks, and a third did not have an identifiable enteric risk. Median eGFR (estimated glomerular filtration rate) at 1-year and at last follow-up were similar between cases and controls except for subgroup of patients with pre-transplant POx >30mcmol/L where 1-year eGFR was lower compared to controls. Across eGFR categories, more cases were in eGFR category 30mcmol/L pre-transplant.

研究背景：本研究描述了本院肾移植受者（不含原发性高草酸尿症患者）的临床特征，并分析移植前伴血浆草酸（plasma oxalate, POx）升高及存在肠道危险因素时的移植肾功能情况。研究方法：纳入2012至2020年间在肾移植评估阶段检测到血浆草酸升高的肾移植受者。采用受者/供者年龄、活体/尸体供肾类型、群体反应性抗体（panel reactive antibody, PRA）、肾脏供者风险指数（kidney donor profile index, KDPI）以及人类白细胞抗原（human leukocyte antigen, HLA）错配数作为匹配变量，构建匹配对照队列。报告病例组与对照组受者术后1年及末次随访时的移植肾功能。研究结果：共纳入106例血浆草酸升高的肾移植受者。其中三分之一患者接受过Roux-en-Y胃旁路术，三分之一存在其他肠道危险因素，剩余三分之一未发现明确肠道危险因素。除移植前血浆草酸>30μmol/L亚组患者的术后1年估算肾小球滤过率（estimated glomerular filtration rate, eGFR）低于对照组外，病例组与对照组的术后1年及末次随访时的中位估算肾小球滤过率均无显著差异。按估算肾小球滤过率分级统计，移植前血浆草酸>30μmol/L的病例中，更多患者属于该分级范畴。