Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers. Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers

We have identified aberrant expression ok key master transcription factor in an AEL patient cohort. The ectopic expression of these factors in mouse erythroid progenitors lead to their transformation in vitro. Then we investigated chromatin accessibility by ATACseq in these models and compared them to normal erythroid progenitors.

本研究在急性红白血病（AEL）患者队列中，鉴定发现关键主控转录因子存在异常表达。将这些因子异位表达于小鼠红系祖细胞后，可诱导其发生体外转化。随后，本研究通过ATAC测序（ATAC-seq）对上述模型的染色质可及性进行了检测，并将检测结果与正常红系祖细胞进行了对比分析。