REFOLDdb

REFOLD has merged to REFOLDdb. REFOLDdb is a unique database for the life sciences research community, providing annotated information for designing new refolding protocols and customizing existing methodologies. We envisage that this resource will find wide utility across broad disciplines that rely on the production of pure, active, recombinant proteins. Furthermore, the database also provides a useful overview of the recent trends and statistics in refolding technology development.We based our resource on the existing REFOLD database, which has not been updated since 2009. We redesigned the data format to be more concise, allowing consistent representations among data entries compared with the original REFOLD database. The remodeled data architecture enhances the search efficiency and improves the sustainability of the database. After an exhaustive literature search we added experimental refolding protocols from reports published 2009 to early 2017. In addition to this new data, we fully converted and integrated existing REFOLD data into our new resource.

REFOLD 已与 REFOLDdb 合并。REFOLDdb 是生命科学研究领域的一个独特数据库，为设计新的折叠策略和定制现有方法提供了注释信息。我们预期，这一资源将在依赖纯化、活性、重组蛋白生产的广泛学科中得到广泛应用。此外，数据库还提供了关于折叠技术发展近期趋势和统计的宝贵概述。我们的资源基于现有的 REFOLD 数据库，该数据库自 2009 年以来未曾更新。我们对数据格式进行了重新设计，使其更加简洁，与原始 REFOLD 数据库相比，数据条目之间实现了一致的表示。重新构建的数据架构提升了搜索效率，并增强了数据库的可持续性。经过彻底的文献检索，我们添加了 2009 年至 2017 年初发表的报告中的实验折叠协议。除了这些新数据外，我们还全面转换并整合了现有的 REFOLD 数据到我们的新资源中。

搜集汇总

背景与挑战

背景概述

REFOLDdb是一个生命科学领域的专业数据库，专注于提供蛋白质重折叠协议的设计和方法定制信息。该数据库整合了2009-2017年的实验数据，并对原有REFOLD数据库进行了重构，提供开放和受限两种数据访问方式。