Heart Rate Dynamics after Combined Strength and Endurance Training in Middle-Aged Women: Heterogeneity of Responses

The loss of complexity in physiological systems may be a dynamical biomarker of aging and disease. In this study the effects of combined strength and endurance training compared with those of endurance training or strength training alone on heart rate (HR) complexity and traditional HR variability indices were examined in middle-aged women. 90 previously untrained female volunteers between the age of 40 and 65 years completed a 21 week progressive training period of either strength training, endurance training or their combination, or served as controls. Continuous HR time series were obtained during supine rest and submaximal steady state exercise. The complexity of HR dynamics was assessed using multiscale entropy analysis. In addition, standard time and frequency domain measures were also computed. Endurance training led to increases in HR complexity and selected time and frequency domain measures of HR variability (P

生理系统的复杂度衰减或许可作为衰老与疾病的动态生物标志物。本研究针对中年女性群体，探究了力量与耐力联合训练、单纯耐力训练或单纯力量训练，对心率（HR）复杂度及传统心率变异性指标的影响。90名此前无训练经验的40至65岁女性志愿者完成了为期21周的渐进式训练，训练方案分为力量训练、耐力训练、联合训练三组，另有一组作为对照组。研究获取了受试者仰卧静息及亚极量稳态运动状态下的连续HR时间序列数据。采用多尺度熵分析（multiscale entropy analysis）对HR动力学复杂度进行评估，同时计算了标准时域与频域指标。耐力训练可提升HR复杂度及部分选定的心率变异性时域与频域指标（P