Pistachio leaf waste transformed into a gut-targeted bioactive phytocomplex

This dataset supports the study "Pistachio leaf waste transformed into a gut-targeted bioactive phytocomplex" published in iScience Journal (https://doi.org/10.1016/j.isci.2025.113345).

The human gut microbiota is integral to host physiology, influencing immune responses, metabolic regulation, and digestion. Disruptions in this microbial community are linked to inflammatory and metabolic disorders. In this study, we explored the potential of Pistachio Leaf Extract (PLE), a polyphenol-rich natural product, to support gut health. The extract, obtained from Pistacia vera leaves harvested in Sicily, was chemically characterized and assessed for prebiotic-like, antimicrobial, antioxidant, and anti-inflammatory effects. It promoted the growth of beneficial gut bacteria, inhibited pathogenic strains, and exhibited marked antioxidant activity. In patient-derived intestinal organoids, the extract reduced inflammation and enhanced antioxidant defenses, with no detectable cytotoxicity in human colon cells. These results suggested that PLE is a safe and multifunctional compound that may contribute to intestinal homeostasis, offering promise for its inclusion in future functional food formulations aimed at promoting gastrointestinal health.

本数据集支撑发表于《iScience》期刊的研究《开心果叶废料转化为肠道靶向生物活性植物复合物》（https://doi.org/10.1016/j.isci.2025.113345）。
人体肠道菌群是宿主生理功能的核心组成部分，可调控免疫应答、代谢过程与消化功能。该微生物群落的失衡与炎症性及代谢性疾病密切相关。本研究探讨了富含多酚的天然产物——开心果叶提取物（Pistachio Leaf Extract，PLE）在维护肠道健康方面的潜力。该提取物取自西西里岛采收的阿月浑子（Pistacia vera）叶片，研究人员对其进行了化学表征，并评估了其类益生元、抗菌、抗氧化及抗炎活性。实验结果显示，该提取物可促进有益肠道菌群增殖，抑制致病菌株生长，并表现出显著的抗氧化活性。在患者来源的肠道类器官模型中，该提取物可减轻炎症反应、增强抗氧化防御能力，且在人类结肠细胞中未检测到细胞毒性。上述结果表明，PLE是一种安全且具有多效性的复合物，可助力维持肠道稳态，为其纳入未来旨在促进胃肠道健康的功能性食品配方提供了应用前景。