The low CD4 response allele, HLA DR*04, limits the efficacy of protective HLA Class I alleles.

Values (other than sample N) in tables represent averages of the indicated variables. BL is baseline score and 012 is twelve-month evaluation point. “NC Decline” is significant neurocognitive decline between BL and 012 (see methods). GDS is ‘global deficit score’ and neurocognitive impairment is defined as ≥0.5. Percent ART is percentage of group on at least 2 anti-retroviral medications. CD4 and CD8 value are absolute cells/microliter. HRNA log is log value of HIV RNA copies/ml with a lower limit of detection of 50 copies. All statistical tests are two tailed, values

表格中除样本编号N外的所有数值，均为对应变量的平均值。BL（baseline score，基线评分）为基线得分，012指代12个月随访评估时点。“NC Decline”指BL与012两个时点间发生的显著神经认知衰退（详见研究方法部分）。GDS（global deficit score，整体缺损评分），神经认知损害的判定标准为评分≥0.5。Percent ART指受试队列中服用至少2种抗逆转录病毒药物的人群占比。CD4与CD8的数值为每微升细胞绝对计数。HRNA log为HIV RNA拷贝数/mL的对数值，其检测下限为50拷贝。所有统计检验均采用双侧检验，数值