A Ligand-Directed Catalytic Regioselective Hydrocarboxylation of Aryl Olefins with Pd and Formic Acid

An
effective Pd-catalyzed hydrocarboxylation of aryl olefins with
Ac2O and formic acid is described. A variety of 2- and
3-arylpropanoic acids can be regioselectively formed by the judicious
choice of ligand without the use of toxic CO gas.

本文报道了一种以乙酸酐（Ac2O）和甲酸（formic acid）为反应试剂，实现芳基烯烃高效钯（Pd）催化氢羧基化的方法。通过合理选择配体，无需使用有毒的一氧化碳（CO）气体，即可区域选择性地合成多种2-芳基丙酸与3-芳基丙酸。