Expression data of primary liver sinusoidal endothelial cells from wild type and LSECs-specific TGF-beta R2 knock out mice

Liver sinusoidal endothelial cells (LSECs) form discontinuous, permeable microvessels, and their characteristic gene expression profile is significantly different from that of continuous microvascular endothelial cells. LSECs play a significant role in maintaining liver homeostasis. The TGF-beta signaling pathway plays a pivotal role in regulating the proliferation and differentiation of LSECs during liver homeostasis. Therefore, we utilized LSEC-specific TGF-beta signaling blockade mice and wild type mice, isolating their primary LSECs to obtain their gene expression profiles.

肝窦内皮细胞（Liver sinusoidal endothelial cells，LSECs）构成不连续且具有通透特性的微血管，其特征性基因表达谱与连续性微血管内皮细胞存在显著差异。该类细胞在维持肝脏稳态中发挥关键作用。转化生长因子-β（TGF-beta）信号通路在肝脏稳态过程中，对肝窦内皮细胞的增殖与分化具有核心调控作用。因此，本研究利用LSEC特异性TGF-beta信号通路阻断小鼠与野生型小鼠，分离其原代肝窦内皮细胞以获取基因表达谱。