Data_Sheet_2_iMAP: A Web Server for Metabolomics Data Integrative Analysis.xlsx

Metabolomics data analysis depends on the utilization of bioinformatics tools. To meet the evolving needs of metabolomics research, several integrated platforms have been developed. Our group has developed a desktop platform IP4M (integrated Platform for Metabolomics Data Analysis) which allows users to perform a nearly complete metabolomics data analysis in one-stop. With the extensive usage of IP4M, more and more demands were raised from users worldwide for a web version and a more customized workflow. Thus, iMAP (integrated Metabolomics Analysis Platform) was developed with extended functions, improved performances, and redesigned structures. Compared with existing platforms, iMAP has more methods and usage modes. A new module was developed with an automatic pipeline for train-test set separation, feature selection, and predictive model construction and validation. A new module was incorporated with sufficient editable parameters for network construction, visualization, and analysis. Moreover, plenty of plotting tools have been upgraded for highly customized publication-ready figures. Overall, iMAP is a good alternative tool with complementary functions to existing metabolomics data analysis platforms. iMAP is freely available for academic usage at https://imap.metaboprofile.cloud/ (License MPL 2.0).

代谢组学（Metabolomics）数据分析依赖于生物信息学（Bioinformatics）工具的应用。为满足代谢组学研究不断发展的需求，学界已开发出多款整合式分析平台。我们团队开发了一款桌面端平台IP4M（integrated Platform for Metabolomics Data Analysis，代谢组学数据分析整合平台），可支持用户一站式完成几乎全流程的代谢组学数据分析工作。随着IP4M的广泛应用，全球用户陆续提出了开发网页版平台以及搭建更个性化分析流程的需求。为此，我们开发了iMAP（integrated Metabolomics Analysis Platform，整合式代谢组学分析平台），该平台拓展了功能、优化了性能并重新设计了架构。相较于现有同类平台，iMAP搭载了更多分析方法与使用模式。平台新增了一个模块，内置自动化流程，可完成训练集与测试集划分、特征筛选、预测模型构建与验证全流程操作。此外还新增了另一模块，配备了充足的可编辑参数，可用于网络构建、可视化与分析工作。不仅如此，平台还对多款绘图工具进行了升级，可生成高度个性化且可直接用于发表的图表。总体而言，iMAP是一款功能互补于现有代谢组学数据分析平台的优质替代工具。iMAP可在https://imap.metaboprofile.cloud/免费用于学术研究（许可证：MPL 2.0）。