Ras/MAPK ASD epistasis top results.

The unique epistatic SNP pairs with P < 2.9x10-9 are listed in the table. For each SNP, the following is listed in order of columns: rsID (Epistatic SNP), chromosome (CHR), position (BP, reference version hg19), minor allele frequency in the ASD dataset (MAF), nearest gene to the epistatic SNP, Ras/MAPK gene associated with the interacting SNP, and P-value for epistasis in cases (Epistasis ASD P) and pseudo-controls (Epistasis Control P). Locus pairs meeting genome-wide significance criteria (P < 7.6 x 10−10) are bolded. Main effects for epistatic and Ras/MAPK SNPs listed here are listed in S4 Table, with no SNPs showing P < 0.01.

本表格列出了所有P值小于2.9×10^-9的独特上位性单核苷酸多态性（Single Nucleotide Polymorphism，简称SNP）对。针对每个SNP，表格列按以下顺序依次展示相关信息：上位性SNP的rs标识符（rsID）、染色体（CHR）、碱基对位置（BP，参考基因组版本为hg19）、自闭症谱系障碍（Autism Spectrum Disorder，ASD）数据集内的次要等位基因频率（MAF）、该上位性SNP的邻近基因、与互作SNP相关的Ras/MAPK基因，以及病例组上位性P值（Epistasis ASD P）和伪对照组上位性P值（Epistasis Control P）。符合全基因组显著性判定标准（P值小于7.6×10^-10）的基因座对已进行加粗标注。本文所列上位性SNP及Ras/MAPK相关SNP的主效应数据已补充至S4表格中，且未出现P值小于0.01的SNP。