Pre-existing skin-resident CD8 and γδ T cell circuits mediate immune response in Merkel cell carcinoma and Predict immunotherapy efficacy [bulkRNA-seq]

Merkel Cell Carcinoma (MCC) is an aggressive skin cancer with limiterd treatment and low response rates to Immune Checkpoint Blockade (ICB) therapy. We compiled the largest sc database of MCC tumor samples and matched blood to identify tumor gener modules that Predict ICB response. MCC tumor and matched blood samples were used for bulk and single-cell RNA-seq. **Raw data is being deposited in dbGaP**

默克尔细胞癌（Merkel Cell Carcinoma, MCC）是一种侵袭性皮肤癌，其治疗手段有限，且对免疫检查点阻断（Immune Checkpoint Blockade, ICB）治疗的应答率较低。本研究构建了目前规模最大的MCC肿瘤样本与配对血液样本的单细胞测序数据库，以识别可预测ICB治疗应答的肿瘤基因模块。研究采用MCC肿瘤样本及配对血液样本进行批量RNA测序（bulk RNA-seq）与单细胞RNA测序（single-cell RNA-seq）。**原始数据正在提交至基因型与表型数据库（dbGaP）**