MMP13-Mediated Fibronectin Degradation Facilitates Coronavirus Attachment to Integrin αvβ3 and Enhances Viral Invasion

This study uncovers a conserved coronavirus strategy in which PEDV infection up-regulates host MMP13 via the IL-1β/JNK pathway. Elevated MMP13 degrades extracellular fibronectin, removing its competitive blockade of PEDV spike–integrin αvβ3 binding and thereby accelerating viral entry. The same MMP13–fibronectin–αvβ3 axis is exploited by SARS-CoV-2 and porcine deltacoronavirus, revealing a potential pan-coronavirus therapeutic target.Data citation requirementThis dataset is released under the Creative Commons Attribution 4.0 International License (CC BY 4.0).If you use any file or derived data, you must cite the dataset: "MMP13-Mediated Fibronectin Degradation Facilitates Coronavirus Attachment to Integrin αvβ3 and Enhances Viral Invasion" Figshare. DOI: 10.6084/m9.figshare.29881502

本研究揭示了一类保守的冠状病毒侵染策略：猪流行性腹泻病毒（Porcine Epidemic Diarrhea Virus, PEDV）感染通过白细胞介素1β（Interleukin-1β, IL-1β）/c-Jun氨基末端激酶（c-Jun N-terminal kinase, JNK）通路上调宿主基质金属蛋白酶13（matrix metalloproteinase 13, MMP13）的表达。上调的MMP13可降解细胞外基质中的纤连蛋白，解除其对PEDV刺突蛋白（spike protein）与整合素αvβ3（integrin αvβ3）结合的竞争性阻断作用，从而加速病毒入侵进程。严重急性呼吸综合征冠状病毒2型（Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV-2）与猪德尔塔冠状病毒（porcine deltacoronovirus）同样利用该MMP13-纤连蛋白-整合素αvβ3信号轴，为泛冠状病毒治疗靶点的开发提供了潜在方向。
数据引用要求
本数据集采用知识共享署名4.0国际许可协议（Creative Commons Attribution 4.0 International License, CC BY 4.0）发布。若您使用本数据集的任意文件或衍生数据，必须引用该数据集：《MMP13介导的纤连蛋白降解促进冠状病毒结合整合素αvβ3并增强病毒入侵》，Figshare，DOI: 10.6084/m9.figshare.29881502