Activation of GPBAR1 by BAR501, a selective synthetic agonist, reduces vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease

The purpose of this study was to evaluate the effect of GPBAR1 activation in a mouse model of atherosclerosis. For this study, Apolipoprotein E deficient mice (ApoE−/−), a standard model of atherosclerosis, were fed with HFD-F alone or in combination with BAR501 for 14 weeks and then sacrificed. The transcriptome analysis of the aorta showed an anti-inflammatory activity of BAR501 that downregulated the expression of many genes belonging to inflammatory pathways.

本研究旨在评估G蛋白偶联胆汁酸受体1（GPBAR1）激活在动脉粥样硬化（atherosclerosis）小鼠模型中的效应。本研究选用动脉粥样硬化的标准模型——载脂蛋白E缺陷小鼠（Apolipoprotein E deficient mice，ApoE−/−），将其分别以单独饲喂HFD-F饲料、联合BAR501饲喂的方式饲养14周，随后实施安乐死。对主动脉开展转录组分析后发现，BAR501具有抗炎活性，可下调多条炎症通路上多种基因的表达水平。