Women with cancer and COVID-19: an analysis of lethality and clinical aspects in Pernambuco

Abstract Objectives: to analyze the lethality and clinical characteristics in Pernambuco women with neoplasia that were infected by SARS-CoV-2. Methods: a cross-sectional, retrospective study with female patients with neoplasm sin the state of Pernambuco registered and made available by the Secretariat of Planning and Management of the State of Pernambuco (SEPLAG PE). Secondary data from public domain notifications and the independent factors associated with death were analyzed through logistic regression. The value ofp<0.25 was considered significant in the bivariate analysis and for a multivariate analysis, the value ofp<0.05 was considered significant. Results: forty-nine women died. The mean age and standard deviation were 58.75 ± 20.93 years. 55.86% of the patients were 60 years old or more. The overall lethality rate was 72.06% (CI95%=59.8 - 82.2). The most prevalent symptoms were fever (70.59%), cough (58.82%), dyspnea (57.35%) and O2 saturation less than 95% (48.53%). Conclusions: female patients, with cancer and infected by SARS-CoV-2 are particularly susceptible to death, regardless of the presence of comorbidities or age, with peripheral O2 saturation <95% being the only independent factor associated with death in this group.

摘要
研究目的：分析伯南布哥州（Pernambuco）感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的女性肿瘤患者的病死率与临床特征。
研究方法：本研究为横断面回顾性研究，研究对象为伯南布哥州规划与管理秘书处（Secretariat of Planning and Management of the State of Pernambuco, SEPLAG PE）登记并公开的伯南布哥州女性肿瘤患者。本研究对公共领域上报的二次病例数据进行分析，通过logistic回归分析与死亡相关的独立危险因素：双变量分析中以P<0.25为差异有统计学意义，多因素分析中以P<0.05为差异有统计学意义。
研究结果：共计49例女性患者死亡。受试者平均年龄为58.75±20.93岁，其中55.86%的患者年龄≥60岁。总体病死率为72.06%（95%置信区间：59.8~82.2）。最常见的临床症状为发热（70.59%）、咳嗽（58.82%）、呼吸困难（57.35%）以及外周血氧饱和度低于95%（48.53%）。
研究结论：合并SARS-CoV-2感染的女性肿瘤患者无论是否存在合并症或年龄因素，均具有较高的死亡易感性；外周血氧饱和度<95%是该群体中唯一与死亡相关的独立危险因素。