Cross-neutralization activity of six select plasma samples from HIV-1 infected Indian individuals against a panel of subtype B and subtype C pseudoviruses.

The neutralization breadth of plasma antibodies from 6 plasma samples obtained from HIV-1 infected ART-naive individuals from India were assessed against a panel of 22 subtype B and C viruses. The AIIMS ID of the plasma samples is provided at the top of the table. Plasma neutralization is shown as the reciprocal value of the ID50, which is the plasma dilution at which virus infectivity is inhibited to 50%. ID50>1000 (Bold), ID50 = 61–1000 (Italic) and 60, where ID50 was not reached. Each experiment was performed at least twice, independently.Cross-neutralization activity of six select plasma samples from HIV-1 infected Indian individuals against a panel of subtype B and subtype C pseudoviruses.

本研究针对由22株B亚型与C亚型HIV-1病毒构成的病毒测试组（virus panel），对6名印度HIV-1感染者且未经抗逆转录病毒治疗（antiretroviral therapy, ART）的血浆样本中的血浆抗体中和广度进行了评估。血浆样本的全印度医学科学研究所（All India Institute of Medical Sciences, AIIMS）编号已在表格顶部列明。血浆中和活性以半数抑制稀释度（ID50）的倒数形式呈现，其中ID50指可将病毒感染性抑制至50%时的血浆稀释倍数。ID50＞1000时以粗体标注，ID50介于61~1000之间时以斜体标注，未达到ID50时对应数值为60。每项实验均独立重复至少2次。本研究同时评估了6份精选血浆样本针对B亚型及C亚型假病毒（pseudovirus）的交叉中和活性。