Parent Questions in Microbiome, Virome and Host Responses Preceding Ventilator-Associated Pneumonia

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Study Description
Microbiome, Virome and Host Responses Preceding Ventilator-Associated Pneumonia (VAP) was a prospective longitudinal observational study of high risk mechanically ventilated children with systematic bacterial and viral analyses of the respiratory tract along with proteomic evaluation of the host response to determine whether specific taxa and patterns of bacterial microbiota contribute to ventilator-associated pneumonia (VAP) risk and whether bacterial communities are modulated by viral infection and host immune responses to increase risk of VAP. Analysis found that in mechanically ventilated children, microbial factors were subtly different at intubation between those who did and did not develop VAP, and changes over time were marginally associated with VAP risk, suggesting other factors may contribute to VAP. Children aged 31 days to 18 years requiring mechanical ventilation support for greater than 72 hours

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研究概况：
呼吸机相关性肺炎（Ventilator-Associated Pneumonia, VAP）发生前的微生物组、病毒组与宿主反应研究是一项针对高风险机械通气儿童的前瞻性纵向观察研究，该研究对受试者呼吸道开展系统性细菌与病毒分析，并对宿主反应进行蛋白质组学评估，旨在明确特定细菌菌群分类群与模式是否会增加呼吸机相关性肺炎（VAP）的发病风险，以及病毒感染与宿主免疫反应是否会通过调控细菌群落进而提升VAP发病风险。
分析结果显示，在机械通气儿童中，插管时已发生VAP与未发生VAP者的微生物特征存在细微差异；随时间推移的微生物变化与VAP风险存在微弱关联，这提示可能存在其他因素参与VAP的发生。本研究纳入的受试者为年龄介于31天至18岁、需接受超过72小时机械通气支持的儿童。